Реакция #90286

Уравнение реакции

hydrochloric acid

3,4-bis-benzyloxy-5-nitro-benzonitrile

sodium azide

ammonium chloride

→

5-(3,4-bis-benzyloxy-5-nitrophenyl)-2H-tetrazole

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling to room temperature
2. 2
   workup.ADDITIONthe reaction mixture was poured onto water (30 mL)
3. 3
   ДругоеThe resulting precipitate was collected
4. 4
   Промывкаwashed with water
5. 5
   Другоеdried

Методика

A mixture of 3,4-bis-benzyloxy-5-nitro-benzonitrile (0.54 g, 1.50 mmol), sodium azide (0.15 g, 2.25 mmol) and ammonium chloride (0.12 g, 2.25 mmol) in dimethylformamide (3 mL) was stirred at 85° C. for 20 hours. After cooling to room temperature, the reaction mixture was poured onto water (30 mL) and acidified with dilute hydrochloric acid. The resulting precipitate was collected, washed with water and dried to yield 5-(3,4-bis-benzyloxy-5-nitrophenyl)-2H-tetrazole, 0.53 g (87%).

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