Реакция #902

Уравнение реакции

2-methyl-3-nitro-6-acetamidobenzoic acid

HCl

→

2-Methyl-3-nitro-6-aminobenzoic acid

Растворители

NaOH

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling to 10° C.
2. 2
   Фильтрацияthe precipitate which deposits is filtered off with suction
3. 3
   Промывкаwashed with water
4. 4
   Другоеdried under reduced pressure at 50° C.

Методика

450 ml of 2N NaOH are initially taken and 75.6 g (0.317 mol) of 2-methyl-3-nitro-6-acetamidobenzoic acid are added. The reaction mixture is then warmed to 95° C. and is stirred at this temperature for one hour. After cooling to 10° C., it is acidified by addition of 425 ml of 2N HCl, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C.

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