Реакция #90163

Уравнение реакции

DMF

methanesulfonic acid (2-fluoropyridin-4-yl)methyl ester

sodium cyanide

→

title compound

Выход 36.0%

(2-Fluoropyridin-4-yl)acetonitrile

Выход 36.0%

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Промывкаwashed with 15% brine
2. 2
   workup.DISTILLATIONdistilled water in order
3. 3
   КонцентрированиеThe organic layer was concentrated
4. 4
   Другоеpurified by silica gel column (n-hexane/ethyl acetate=5/1)

Методика

To the DMF (28 ml) solution of methanesulfonic acid (2-fluoropyridin-4-yl)methyl ester (1.16 g), sodium cyanide (0.42 g) was added and the mixture was stirred at 80° C. for 1 hr. The mixture was diluted with ethyl acetate (100 ml), and washed with 15% brine and distilled water in order. The organic layer was concentrated and purified by silica gel column (n-hexane/ethyl acetate=5/1) to obtain the title compound (278 mg, 36%).

Источник