Реакция #89812

Уравнение реакции

4-chloro-2-(3-nitrophenyl)quinazoline

tert-butyl 5-amino-1H-indazole-1-carboxylate

→

tert-butyl 5-(2-(3-nitrophenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Растворители

isopropanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe suspension was filtered
2. 2
   Промывкаthe filtered solid was washed with isopropanol
3. 3
   ДругоеThe product was dried under high vacuum for several hours

Методика

A suspension of 4-chloro-2-(3-nitrophenyl)quinazoline (6.3 g, 21.9 mmole), tert-butyl 5-amino-1H-indazole-1-carboxylate (5.10 g, 21.9 mmole) in isopropanol (300 mL) was heated at 95° C. for 1.5 h. The suspension was filtered and the filtered solid was washed with isopropanol. The product was dried under high vacuum for several hours to give the desired product tert-butyl 5-(2-(3-nitrophenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate. (8.3 g, mmol, 79%).

Источник