Реакция #89703

Уравнение реакции

diisopropylethylamine

piperidine-2,3-dicarboxylic acid 3-tert-butyl ester

4-(3-isopropyl-phenyl)-1,2,3,6-tetrahydropyridine

PyBOP

→

4-(3-Isopropyl-phenyl-3,6-dihydro-2H-pyridine-1-carbonyl]-piperidine-3-carboxylic acid tert-butyl ester

Растворители

EtOAc

DMF

Условия реакции

Обработка

1. 1
   Промывкаwashed with saturated NaHCO3 solution (×3), water, and brine
2. 2
   СушкаThe organic layers were dried over MgSO4
3. 3
   Фильтрацияfiltered
4. 4
   Концентрированиеconcentrated
5. 5
   Другоеto dry under reduced pressure

Методика

To a 0° C. solution of piperidine-2,3-dicarboxylic acid 3-tert-butyl ester (100 mg) in DMF (0.6 mL) was added sequentially, 4-(3-isopropyl-phenyl)-1,2,3,6-tetrahydropyridine (97 mg). PyBOP (232 mg), and diisopropylethylamine (0.152 mL). The resultant mixture was stirred at rt overnight. The reaction solution was diluted with EtOAc and washed with saturated NaHCO3 solution (×3), water, and brine. The organic layers were dried over MgSO4, filtered, and concentrated to dry under reduced pressure. The residue was used in next step without further purifications. MS (ESI): 413.2 (M+H+)

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