Реакция #89694

Уравнение реакции

(2S)-benzylamino-succinic acid 1-benzyl ester 4-tert-butyl ester

K2CO3

NaI

3-chloro-2-chloromethyl-1-propene

→

(2S)-[benzyl-(2-chloromethyl-allyl)-amino]-succinic acid 1-benzyl ester 4-tert-butyl ester

Выход 58.3%

Растворители

MeCN

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling
2. 2
   Фильтрацияthe reaction mixture was filtered
3. 3
   Концентрированиеthe filtrate was concentrated under reduced pressure
4. 4
   ДругоеPurification by Combiflash (hexane and ethyl acetate: gradient 0 to 8% during 12 min)

Методика

A mixture of (2S)-benzylamino-succinic acid 1-benzyl ester 4-tert-butyl ester (12.1 g, 32.6 mmol), K2CO3 (14 g, 3 equiv.), NaI (3.0 g, 20 mmol) and 3-chloro-2-chloromethyl-1-propene (5.1 g, 40.8 mmol) in MeCN (150 mL) was stirred at 81° C. for 16 h. After cooling, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. Purification by Combiflash (hexane and ethyl acetate: gradient 0 to 8% during 12 min) afforded (2S)-[benzyl-(2-chloromethyl-allyl)-amino]-succinic acid 1-benzyl ester 4-tert-butyl ester (8.7 g, 58%). MS (ESI): 458 (M+Na+).

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