Реакция #89620

Уравнение реакции

Isoprene

dimethyl maleate

→

4-methyl-cyclohex-4-ene-1,2-dicarboxylic acid dimethyl ester

Выход 66.7%

Условия реакции

Обработка

1. 1
   ДругоеThe autoclave was sealed
2. 2
   ТемператураThe temperature of the autoclave increased to 195° C. due to the
3. 3
   Температураheat of the reaction
4. 4
   Другоеthe completion of the reaction
5. 5
   ТемператураThe autoclave was then cooled to room temperature
6. 6
   workup.DISTILLATIONSimple distillation of the resulting mixture

Методика

Isoprene (350 g, 5.1 mol) and dimethyl maleate (741 g, 5.1 mol) were loaded into a stainless steel autoclave. The autoclave was sealed and heated to 150° C. The temperature of the autoclave increased to 195° C. due to the heat of the reaction. The temperature was held at 160° C. for 1 hour. Gas chromatography (GC) analysis indicated the completion of the reaction. The autoclave was then cooled to room temperature. Simple distillation of the resulting mixture provided 4-methyl-cyclohex-4-ene-1,2-dicarboxylic acid dimethyl ester (725 g, 3.4 mol, 66% yield) as a light yellow liquid.

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