Реакция #88901

Уравнение реакции

(5-Fluoro-pyridin-2-yl)-hydrazine

diethoxymethyl acetate

→

6-Fluoro-[1,2,4]triazolo[4,3-a]pyridine

Растворители

cyclohexane

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered
2. 2
   Другоеto give Intermediate Fa (379 mg, 70%)

Методика

(5-Fluoro-pyridin-2-yl)-hydrazine (500 mg, 3.93 mmol) in diethoxymethyl acetate (5 mL) was stirred at RT for 2 h. The resulting precipitate was diluted with cyclohexane (5 mL) and filtered to give Intermediate Fa (379 mg, 70%). 1H NMR (400 MHz, CDCl3): 7.25 (1H, m), 7.84 (1H, m), 8.09 (1H, t, J=2.5 Hz), 8.84 (1H, s).

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