Реакция #88885

Уравнение реакции

tert-butyl 4-(2,4-difluorobenzyl)-4-hydroxypiperidine-1-carboxylate

HCl ethanol

→

title compound

4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was evaporated under reduced pressure
2. 2
   Другоеthe obtained solid was recrystallized from ethyl acetate/diisopropyl ether

Методика

To a solution of tert-butyl 4-(2,4-difluorobenzyl)-4-hydroxypiperidine-1-carboxylate (3.7 g) in ethanol (30 mL) was added 2.0 M HCl/ethanol solution (28 mL), and the mixture was stirred overnight at room temperature. The solvent was evaporated under reduced pressure, and the obtained solid was recrystallized from ethyl acetate/diisopropyl ether to give the title compound (2.9 g).

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