Реакция #88870

Уравнение реакции

tert-butyl 4-(4-fluorobenzyl)-4-hydroxypiperidine-1-carboxylate

HCl ethanol

→

title compound

4-(4-fluorobenzyl)-4-hydroxypiperidine hydrochloride

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was evaporated under reduced pressure
2. 2
   Другоеthe obtained solid was recrystallized from ethanol/hexane

Методика

To a solution of tert-butyl 4-(4-fluorobenzyl)-4-hydroxypiperidine-1-carboxylate (2.0 g) in ethanol (10 mL) was added 2.0 M HCl/ethanol solution (20 mL), and the mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, and the obtained solid was recrystallized from ethanol/hexane to give the title compound (1.4 g).

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