Реакция #88400

Уравнение реакции

sodium hydroxide

methyl 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate

→

title compound

sodium 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate

Растворители

methanol

Условия реакции

Обработка

1. 1
   Другоеobtained in (Example 2.2) <Step 1>
2. 2
   Температураthe obtained mixture was then heated
3. 3
   Температураto reflux for 15 minutes
4. 4
   workup.DISTILLATIONThereafter, the solvent was distilled away under reduced pressure

Методика

An aqueous solution (1 ml) of sodium hydroxide (9.6 mg) was added to a methanol (1 ml) solution of the methyl 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate (30 mg) obtained in (Example 2.2) <Step 1>, and the obtained mixture was then heated to reflux for 15 minutes. Thereafter, the solvent was distilled away under reduced pressure, and the residue was then subjected to azeotropy with toluene, so as to obtain a crude product of the title compound.

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