Реакция #88078

Уравнение реакции

methyl iodide

3-iodo-4-methyl-5-nitro-benzoic acid

K2CO3

→

3-iodo-4-methyl-5-nitro-benzoic acid methyl ester

Выход 98.3%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураcooled to room temperature
2. 2
   Другоеpartitioned between ethyl acetate and brine
3. 3
   ДругоеThe organic layer was separated
4. 4
   Сушкаdried over MgSO4
5. 5
   Фильтрацияfiltered
6. 6
   Концентрированиеconcentrated under reduced pressure

Методика

To a solution of 3-iodo-4-methyl-5-nitro-benzoic acid (16.06 g, 52.3 mmol) in acetone (300 mL) was added K2CO3 (14.46 g, 104.6 mmol) followed by methyl iodide ((3.91 mL, 62.76 mmol). The reaction mixture was stirred at 40° C. overnight, then cooled to room temperature and partitioned between ethyl acetate and brine. The organic layer was separated, dried over MgSO4, filtered and concentrated under reduced pressure to provide 16.5 g (98%) of 3-iodo-4-methyl-5-nitro-benzoic acid methyl ester.

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