Реакция #87674

Уравнение реакции

2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoyl isocyanate

tert-butyl 2-(3-chloro-4-methylphenyl)hydrazinecarboxylate

trifluoro acetic acid

→

desired product

Выход 26.1%

N-(4-chloro-3-(1-(3-chloro-4-methylphenyl)-4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)benzyl)-2,2,2-trifluoroacetamide

Выход 26.1%

Растворители

DCM

Условия реакции

Обработка

1. 1
   ДругоеThe title compound was prepared

Методика

The title compound was prepared according to the procedure described in Example-83 by using 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoyl isocyanate (step-3 of Intermediate-26, 0.500 g, 1.55 mmol), tert-butyl 2-(3-chloro-4-methylphenyl)hydrazinecarboxylate (Intermediate-87, 0.450 g, 1.55 mmol), DCM (20 mL) and trifluoro acetic acid (5.0 mL) to afford 0.180 g of the desired product.

Источник