Реакция #87647

Уравнение реакции

2-chloro-4-methoxybenzoic acid

2,2,2-trifluoro-N-(hydroxymethyl)acetamide

H2SO4

→

desired product

Выход 39.9%

5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoic acid

Выход 39.9%

Условия реакции

Обработка

1. 1
   ДругоеThe title compound was prepared

Методика

The title compound was prepared according to the procedure described in step-1 of Intermediate-26 by using 2-chloro-4-methoxybenzoic acid (0.060 g), 2,2,2-trifluoro-N-(hydroxymethyl)acetamide (0.050 g) and H2SO4 (2 mL) to afford 0.040 g of the desired product.

Источник