Реакция #87602

Уравнение реакции

2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid

HCl

→

5-(aminomethyl)-2-chlorobenzoic acid hydrochloride

Растворители

methanol

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture was refluxed for 18 h
2. 2
   КонцентрированиеThe reaction mixture was concentrated
3. 3
   Другоеcrude reaction mixture

Методика

To a solution of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid (step-1 of Intermediate-26, 10.0 g, 35.50 mmol) in methanol (100 mL) was added conc. HCl (10 mL). The reaction mixture was refluxed for 18 h. The reaction mixture was concentrated and crude reaction mixture was used for next step.

Источник