Реакция #87404

Уравнение реакции

6-[(Cyclopropylmethoxy)methyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one

bromoacetic acid

sodium hydroxide

→

title compound

Выход 37.0%

6-[(Cyclopropylmethoxy)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Выход 37.0%

Растворители

EtOH

H2O

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture was refluxed for 16 h
2. 2
   КонцентрированиеThe mixture was concentrated in vacuo and hydrochloric acid (aq, 10%)
3. 3
   workup.ADDITIONwas added
4. 4
   ДругоеThe precipitate was isolated by filtration
5. 5
   Другоеdried

Методика

6-[(Cyclopropylmethoxy)methyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one (10.3 g, 48.5 mmol) was added to bromoacetic acid (21.5 g, 155 mmol, 3.2 eq) in EtOH (108 mL) and H2O (441 mL). The reaction mixture was refluxed for 16 h then cooled down to rt and basified to pH˜10 with sodium hydroxide (3 M, aq). The mixture was concentrated in vacuo and hydrochloric acid (aq, 10%) was added. The mixture was cooled to 0° C. The precipitate was isolated by filtration and dried to give the title compound as a solid (3.5 g, 37%).

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