Реакция #8717

Уравнение реакции

2-(2-ethoxyphenyl)-6-methyl-8-propyl-3H-imidazo[1,5-a][1,3,5]triazin-4-one

chlorosulfonic acid

→

4-ethoxy-3-(6-methyl-4-oxo-8-propyl-3,4-dihydro-imidazo[1,5-a][1,3,5]triazin-2-yl)-benzene-sulfonyl chloride

Выход 99.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Температураwhile cooling with ice
2. 2
   workup.ADDITIONpoured onto ice water
3. 3
   ПромывкаThe organic phase is washed with water
4. 4
   Сушкаdried over magnesium sulfate
5. 5
   Другоеthe solvent is removed in vacuo

Методика

1.64 g (5.25 mmol) of 2-(2-ethoxyphenyl)-6-methyl-8-propyl-3H-imidazo[1,5-a][1,3,5]triazin-4-one (example VI) are added in portions to 3.14 ml of chlorosulfonic acid while cooling with ice. The reaction mixture is stirred at room temperature for 16 hours, then diluted with dichloromethane and poured onto ice water. The organic phase is washed with water and dried over magnesium sulfate and the solvent is removed in vacuo. 2.15 g (99%) of 4-ethoxy-3-(6-methyl-4-oxo-8-propyl-3,4-dihydro-imidazo[1,5-a][1,3,5]triazin-2-yl)-benzene-sulfonyl chloride are obtained.

Источник