Реакция #87107

Уравнение реакции

benzonitrile

DIPEA

tert-butyl ((2S)-4-methyl-3-oxo-1-(2-oxopyrrolidin-3-yl)pent-4-en-2-yl)carbamate

H2O2

→

tert-butyl ((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-(-2-oxopyrrolidin-3-yl) propan-2-yl)carbamate

Выход 45.4%

Растворители

water

methanol

Условия реакции

Обработка

1. 1
   ЭкстракцияThe resulting mixture was extracted with EtOAc (50 mL×2)
2. 2
   ПромывкаThe combined extracts were washed with brine
3. 3
   Сушкаdried over anhydrous sodium sulfate
4. 4
   Концентрированиеconcentrated
5. 5
   ДругоеThe residue was purified by flash column chromatography on silica gel (heptanes/EtOAc=2:1)

Методика

To a solution of tert-butyl ((2S)-4-methyl-3-oxo-1-(2-oxopyrrolidin-3-yl)pent-4-en-2-yl)carbamate (200 mg, 0.67 mmol) in methanol (10 mL) at 0° C. was added 30% H2O2 (1.5 g, 1.4 mmol) followed by addition of benzonitrile (520 mg, 5.00 mmol) and DIPEA (0.87 mL, 5.0 mmol). The reaction mixture was stirred for 8 h at ambient temperature and then diluted with water (25 mL). The resulting mixture was extracted with EtOAc (50 mL×2). The combined extracts were washed with brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by flash column chromatography on silica gel (heptanes/EtOAc=2:1) to afford tert-butyl ((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-(-2-oxopyrrolidin-3-yl) propan-2-yl)carbamate (95 mg, 45% yield) as a yellow oil.

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