Реакция #8708

Уравнение реакции

4,6-dichloro-5-(4-chlorophenyl)pyrimidine

2-thiophen-2-yl-ethanesulfonic acid amide potassium salt

Hunig's base

→

2-thiophen-2-yl-ethanesulfonic acid [6-chloro-5-(4-chloro-phenyl)-pyrimidin-4-yl]-amide

Выход 68.7%

Растворители

DMSO

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted twice with diethyl ether
2. 2
   ДругоеThe precipitate was collected
3. 3
   Промывкаwashed with water and diethyl ether
4. 4
   Другоеdried

Методика

A solution of 4,6-dichloro-5-(4-chlorophenyl)pyrimidine (848 mg), 2-thiophen-2-yl-ethanesulfonic acid amide potassium salt (1.5 g, Referential Example 14) and Hunig's base (1 ml) in DMSO (20 ml) was stirred at rt for 24 h before it was diluted with water (200 ml) and extracted twice with diethyl ether. The aqueous layer was acidified with acetic acid. The precipitate was collected, washed with water and diethyl ether and dried to give 2-thiophen-2-yl-ethanesulfonic acid [6-chloro-5-(4-chloro-phenyl)-pyrimidin-4-yl]-amide (930 mg) as a beige powder. LC-MS: tR=5.01 min, [M+1]+=413.49, [M−1]−=411.93.

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