Реакция #8698

Уравнение реакции

4,6-dichloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine

2-phenyl-ethanesulfonic acid amide potassium salt

→

2-phenyl-ethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide

Выход 78.1%

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеBulk of the solvent was evaporated before it
2. 2
   workup.ADDITIONwas diluted with diethyl ether (50 ml)
3. 3
   ДругоеThe precipitate that formed
4. 4
   Другоеwas collected
5. 5
   Промывкаwashed with diethyl ether (100 ml)
6. 6
   Другоеdried

Методика

A solution of 4,6-dichloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine (2 g) and 2-phenyl-ethanesulfonic acid amide potassium salt (2.82 g, Referential Example 1e) in DMF (50 ml) was stirred at rt for 16 h. Bulk of the solvent was evaporated before it was diluted with diethyl ether (50 ml). The mixture was acidified with 10% aq. citric acid. The precipitate that formed was collected, washed with diethyl ether (100 ml) and dried to give 2-phenyl-ethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide (2.23 g) as a beige powder. LC-MS: tR=4.93 min, [M+1]+=497.22, [M−1]−=494.96.

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