Реакция #869

Уравнение реакции

HCl dioxane

N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine

→

(R)-α-methoxymethylbenzylamine hydrochloride

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was concentrated under reduced pressure
2. 2
   workup.ADDITION30 ml of ether were added to the residue
3. 3
   Концентрированиеthis was further concentrated

Методика

60 ml of 4N-HCl/dioxane solution was added to 4.02 g (16.0 mmols) of N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. 30 ml of ether were added to the residue, and this was further concentrated to obtain (R)-α-methoxymethylbenzylamine hydrochloride in quantitative yield.

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