Реакция #86830

Уравнение реакции

Sodium hydroxide

(S)-methyl 2-(1-cyclohexyl-2-hydroxyethylamino)-2-oxoacetate

hydrochloric acid

→

(S)-2-(1-cyclohexyl-2-hydroxyethylamino)-2-oxoacetic acid

Выход 56.5%

Условия реакции

Обработка

1. 1
   Фильтрацияthe resulting precipitate was collected by filtration
2. 2
   Промывкаwashed with water
3. 3
   Другоеdried

Методика

Sodium hydroxide 1M (8.7 mL; 8.7 mmol) was added to (S)-methyl 2-(1-cyclohexyl-2-hydroxyethylamino)-2-oxoacetate (0.660 g; 2.88 mmol) and the mixture was stirred at room temperature for 2 hours. The solution was acidified to pH 0-1 by addition of concentrated hydrochloric acid and the resulting precipitate was collected by filtration, washed with water, and dried to afford 0.350 g (56%) of (S)-2-(1-cyclohexyl-2-hydroxyethylamino)-2-oxoacetic acid as a white solid.

Источник