Реакция #86668

Уравнение реакции

Carboxylic acid

(S)-2-Benzyloxycarbonylamino-but-3-enoic acid methyl ester

thionyl chloride

→

(S)-2-Amino-but-3-enoic acid methyl ester hydrochloride

Растворители

methanol

Условия реакции

Обработка

1. 1
   ТемператураThis was cooled in ice
2. 2
   Концентрированиеat rt for 18 h before being concentrated in vacuo
3. 3
   Другоеto afford a white solid, 0.388 g, (100%)

Методика

Carboxylic acid 62 (0.350 g, 2.56 mmol) was suspended in methanol (10 mL). This was cooled in ice and 20% (v/v) thionyl chloride was added portionwise. The solution was stirred in ice for 1 h and then at rt for 18 h before being concentrated in vacuo to afford a white solid, 0.388 g, (100%).

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