Реакция #86599

Уравнение реакции

benzyl 1-(2-(isopentylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

→

2-(3-Amino-2-oxopyridin-1(2H)-yl)-N-isopentylacetamide

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеThe catalysis is separated by filtration over silica gel, before the solvent
2. 2
   Другоеis removed in vacuo
3. 3
   ДругоеGreen solid is obtained
4. 4
   Другоеit is suitable for further processing without purification

Методика

573 mg of benzyl 1-(2-(isopentylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate (ZED1020, 1.54 mmol) are dissolved under nitrogen atmosphere in 100 mL of ethanol. To this solution 50 mg of Pd/C (10%) is added and stirred under hydrogen atmosphere at atmosphere pressure for 1 h at RT. The catalysis is separated by filtration over silica gel, before the solvent is removed in vacuo. Green solid is obtained and it is suitable for further processing without purification.

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