Реакция #86594

Уравнение реакции

benzyl-1-(2-(2-ethylbutylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-yl-carbamate

→

2-(3-Amino-2-oxopyridin-1(2H)-yl)-N-(2-ethylbutyl)acetamide

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеThe catalysis is separated by filtration over silica gel, before the solvent
2. 2
   Другоеis removed in vacuo
3. 3
   ДругоеDark oil is obtained
4. 4
   Другоеit is suitable for further processing without further purification

Методика

5.22 g of benzyl-1-(2-(2-ethylbutylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-yl-carbamate (2.4, ˜11.2 mmol) are dissolved under nitrogen atmosphere in 60 mL of methanol. To this solution, 500 mg of Pd/C (10%) are added and stirred under hydrogen atmosphere at atmosphere pressure for 2.5 h. The catalysis is separated by filtration over silica gel, before the solvent is removed in vacuo. Dark oil is obtained and it is suitable for further processing without further purification.

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