Реакция #8628

Уравнение реакции

2-(2-hydroxyethyl)-4-(1-methylcarbamoyl-2-naphthalen-2-ylethyl)piperazine-1-carboxylic acid tert-butyl ester

acetic anhydride

pyridine

→

desired product

2-(2-acetoxyethyl)-4-(1-methylcarbamoyl-2-naphthalen-2-ylethyl)-piperazine-1-carboxylic acid tert-butyl ester

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ЭкстракцияThe solution is then extracted with water and 1 n HCl
2. 2
   ДругоеThe organic phase is dried
3. 3
   Концентрированиеconcentrated in vacuo
4. 4
   Другоеthe resulting crude product purified over silica gel (EtOAc/hexane 1:3

Методика

A solution of 2-(2-hydroxyethyl)-4-(1-methylcarbamoyl-2-naphthalen-2-ylethyl)piperazine-1-carboxylic acid tert-butyl ester, 60, (4.4 g, 10 mmol), acetic anhydride (13 mL), pyridine (1 mL) and N,N-dimethylaminopyridine (0.25 g) in dichloromethane (50 mL) is stirred for 1.5 hours. The solution is then extracted with water and 1 n HCl. The organic phase is dried, concentrated in vacuo, and the resulting crude product purified over silica gel (EtOAc/hexane 1:3 then 1:1) to afford the desired product.

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