Реакция #86059

Уравнение реакции

5-methyl-4-((3-phenyl-isoxazol-5-yl)-methoxy-)-thieno[2,3-d]pyrimidine

dichloromethane

acetic acid

→

5-methyl-4-((3-phenyl-isoxazol-5-yl)-methoxy-)-thieno[2,3-d]pyrimidine acetate

Выход 58.0%

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe mixture was stirred for 1-2 hours at 30-40
2. 2
   ТемператураThe mixture was cooled down
3. 3
   Другоеcrystallized
4. 4
   Фильтрацияfiltered
5. 5
   Другоеdried under vacuum

Методика

0.5 mmol of 5-methyl-4-((3-phenyl-isoxazol-5-yl)-methoxy-)-thieno[2,3-d]pyrimidine was added into a 50 ml single-necked round-bottom flask containing 10 ml of dry dichloromethane. 2 ml of acetic acid was added under stirring, and the mixture was stirred for 1-2 hours at 30-40. The mixture was cooled down, crystallized, filtered and dried under vacuum to afford 5-methyl-4-((3-phenyl-isoxazol-5-yl)-methoxy-)-thieno[2,3-d]pyrimidine acetate as a colorless solid in 58% yield.

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