Реакция #85428

Уравнение реакции

compound 125-C

(3,4-Difluoro-benzyl)-(3-methyl-benzo[b]thiophen-2-yl)-carbamic acid tert-butyl ester

→

(3,4-Difluoro-benzyl)-(3-methyl-benzo[b]thiophen-2-yl)-amine

Растворители

dichloromethane

trifluoroacetic acid

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was evaporated in vacuo
2. 2
   Другоеthe residue partitioned between dichloromethane and saturated aqueous sodium bicarbonate
3. 3
   СушкаThe organic layer was dried over sodium sulfate
4. 4
   Другоеthe solvent evaporated in vacuo
5. 5
   Другоеto afford compound 125-D as a colorless solid (1.86 g, 93%)

Методика

A solution of compound 125-C (2.7 g, 6.9 mmol) in dichloromethane (40 mL) and trifluoroacetic acid (40 mL) was stirred at rt for 4 h. The solvent was evaporated in vacuo, and the residue partitioned between dichloromethane and saturated aqueous sodium bicarbonate. The organic layer was dried over sodium sulfate, and the solvent evaporated in vacuo to afford compound 125-D as a colorless solid (1.86 g, 93%). 1H-NMR (CDCl3): δ 2.16 (s, 3H), 4.37 (s, 2H), 7.09-7.32 (m, 5H), 7.40 (d, 1H), 7.60 (d, 1H); MS: m/z 290.1 (MH+).

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