Реакция #8536

Уравнение реакции

2,3,4-Trifluoronitrobenzene

pyruvic acid

→

title compound

Выход 96.0%

2-(2,3,4-Trifluoroanilino)propionic acid

Выход 96.0%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ФильтрацияAfter filtering off Pd—C
2. 2
   Концентрированиеthe obtained filtrate was concentrated under reduced pressure

Методика

2,3,4-Trifluoronitrobenzene (1.01 g) and pyruvic acid (0.75 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 4.9 MPa (converted from 50 kgf/cm2) for 5 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.20 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

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