Реакция #8535

Уравнение реакции

2,3,4-Trifluoronitrobenzene

pyruvic acid

→

title compound

Выход 97.8%

2-(2,3,4-Trifluoroanilino)propionic acid

Выход 97.8%

Растворители

IPA

Условия реакции

Обработка

1. 1
   ФильтрацияAfter filtering off Pd—C
2. 2
   Концентрированиеthe obtained filtrate was concentrated under reduced pressure

Методика

2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.09 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Источник