Реакция #8530

Уравнение реакции

hydrochloric acid

2,3,4-Trifluoroaniline

methyl pyruvate

→

title compound

Выход 81.8%

Methyl 2-(2,3,4-trifluoroanilino)propionate

Выход 81.8%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ФильтрацияAfter filtering off Pd—C
2. 2
   Концентрированиеthe obtained filtrate was concentrated under reduced pressure

Методика

2,3,4-Trifluoroaniline (1.01 g) and methyl pyruvate (0.87 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g) and conc. hydrochloric acid (0.03 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa (converted from 30 kgf/cm2) for 2 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.31 g) was obtained as slightly yellowish crystals. Various spectral data of this product was identical with those obtained in Example 5.

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