Реакция #8528

Уравнение реакции

hydrogen

2,3,4-Trifluoronitrobenzene

methyl pyruvate

ethanol

magnesium sulfate

→

title compound

Ethyl 2-(2,3,4-trifluoroanilino)propionate

Растворители

ethyl acetate normal hexane

Условия реакции

Обработка

1. 1
   ФильтрацияAfter filtering off Pd—C and magnesium sulfate
2. 2
   Концентрированиеthe obtained filtrate was concentrated under reduced pressure
3. 3
   ДругоеThe residue thus obtained

Методика

2,3,4-Trifluoronitrobenzene (3.54 g) and methyl pyruvate (2.32 g) were dissolved in ethanol (30 ml). After adding 5% Pd—C (2.0 g) and anhydrous magnesium sulfate (2.65 g), the mixture was stirred at 50° C. in a hydrogen atmosphere for 16 hours. After filtering off Pd—C and magnesium sulfate, the obtained filtrate was concentrated under reduced pressure. The residue thus obtained was subjected to silica gel column chromatography (ethyl acetate-normal hexane=1:4) to give the title compound (4.84 g) as a pale yellow oily substance.

Источник