Реакция #84542

Уравнение реакции

cyclohexanol

ethyl 2-diazoacetate

→

title compound

Выход 85.4%

ethyl 2-(cyclohexyloxy)acetate

Выход 85.4%

Растворители

DCM

Условия реакции

Обработка

1. 1
   ФильтрацияIt was then filtered
2. 2
   Концентрированиеthe filtrate was concentrated in vacuo
3. 3
   ДругоеThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=15:1)

Методика

To a mixture of cyclohexanol (2.40 g, 24.0 mmol) and Rh2(OAc)4 (50 mg, 0.11 mmol) in DCM (50 mL) was added ethyl 2-diazoacetate (2.73 g, 23.9 mmol) and the mixture was stirred at rt for 5 min. It was then filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=15:1) to give the title compound as colorless oil (3.8 g, 85%).

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