Реакция #84465

Уравнение реакции

2-(piperidin-1-yl)ethanamine

K2CO3

1,2-difluoro-4-nitrobenzene

→

crude product

2-fluoro-4-nitro-N-(2-(piperidin-1-yl)ethyl)aniline

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураthe mixture was refluxed overnight
2. 2
   Фильтрацияfiltered
3. 3
   КонцентрированиеThe filtrate was concentrated in vacuo

Методика

To a suspension of 2-(piperidin-1-yl)ethanamine (0.90 g, 7.02 mmol) and K2CO3 (0.97 g, 7.02 mmol) in acetone (30 mL) was added 1,2-difluoro-4-nitrobenzene (1.11 g, 6.98 mmol) in one portion in an ice bath and the mixture was refluxed overnight, cooled to rt and filtered. The filtrate was concentrated in vacuo to give the crude product, which was used for next step without further purification.

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