Реакция #84404

Уравнение реакции

tert-butyl (2-fluoro-5-morpholinophenyl)carbamate

HCl

→

title compound

Выход 57.0%

2-fluoro-5-morpholinoaniline

Выход 57.0%

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water (150 mL)
3. 3
   Экстракцияextracted with CH2Cl2 (100 mL×3)
4. 4
   ПромывкаThe combined organic phases were washed with brine (150 mL)
5. 5
   Сушкаdried over anhydrous Na2SO4
6. 6
   Концентрированиеconcentrated in vacuo

Методика

A mixture of tert-butyl (2-fluoro-5-morpholinophenyl)carbamate (0.93 g, 3.14 mmol) and a solution of HCl (31 mL, 31 mmol, 1 M in MeOH) was stirred at rt overnight, then concentrated in vacuo. The residue was dissolved in water (150 mL). The soltution was basified with saturated Na2CO3 aqueous solution and extracted with CH2Cl2 (100 mL×3). The combined organic phases were washed with brine (150 mL), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a light brown solid (0.35 g, 57%).

Источник