Реакция #84341

Уравнение реакции

2-bromo-1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone

methoxyamine hydrochloride

→

desired product

Выход 84.9%

2-bromo-1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone-O-methyloxime

Выход 84.9%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеAfter completion of the reaction
2. 2
   Другоеthe solvent was evaporated under reduced pressure
3. 3
   Другоеthe resulting residue was purified by silica gel column chromatography

Методика

To 1.3 g of 2-bromo-1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone in 10 ml of ethanol, 362 mg of methoxyamine hydrochloride was added, and the mixture was stirred at room temperature for 13 hours. After completion of the reaction, the solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 0:100 to 5:95) to obtain 1.2 g of the desired product as a colorless oil.

Источник