Реакция #84069

Уравнение реакции

4-(6-hydroxyquinolin-2-yl)benzonitrile

NH2OH.HCl

→

desired product

Выход 78.0%

N-hydroxy-4-(6-hydroxyquinolin-2-yl)benzimidamide

Выход 78.0%

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Концентрированиеfollowed by concentration in vacuo
2. 2
   workup.STIRRINGstirred for 1 hour
3. 3
   ФильтрацияFiltration
4. 4
   Другоеdrying of the solids

Методика

See Scheme 4, route B. 4-(6-hydroxyquinolin-2-yl)benzonitrile (900 mg, 3.68 mmol) was dissolved in 25 mL of EtOH and to it was added NH2OH.HCl (500 mg, 7.36 mmol) and TEA (1.5 mL). The mixture was stirred at 80° C. for 2 hours followed by concentration in vacuo. The crude solids were then suspended in 25 mL of H2O and stirred for 1 hour. Filtration and drying of the solids yielded desired product (800 mg, 78% yield).

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