Реакция #84066

Уравнение реакции

4-cyanophenylboronic acid

2,4-dichloro-6-methoxyquinoline

→

desired product

4-(4-chloro-6-methoxyquinolin-2-yl)benzonitrile

Растворители

DMF

Условия реакции

Обработка

1. 1
   Температураto cool
2. 2
   ДругоеThe resulting solid was isolated by filtration
3. 3
   Промывкаwashed with water
4. 4
   Другоеdried
5. 5
   Другоеfollowed by recrystallization from methanol

Методика

Followed Scheme 2, Step 1 starting from 4-cyanophenylboronic acid and 2,4-dichloro-6-methoxyquinoline, where the solvent used was DMF, and the catalyst used was Pd(PPh3)4. The mixture was heated to 100° C. for 3 h, allowed to cool, and then poured into ice water. The resulting solid was isolated by filtration, washed with water, and dried followed by recrystallization from methanol to give the desired product.

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