Реакция #84049

Уравнение реакции

methyl 6-bromo-1-benzothiophene-2-carboxylate

potassium hydroxide

→

desired product

6-Bromo-1-benzothiophene-2-carboxylic acid

Растворители

THF

Условия реакции

Обработка

1. 1
   ДругоеThe solvent is removed in vacuo
2. 2
   ФильтрацияThe resulting precipitate is filtered off with suction
3. 3
   Промывкаwashed with water
4. 4
   Другоеdried in vacuo at 50° C

Методика

A solution of 4.0 g (14.8 mmol) of methyl 6-bromo-1-benzothiophene-2-carboxylate in 40 ml of a 1:1 mixture of THF and 2 N potassium hydroxide solution is stirred at room temperature for 2 h. The solvent is removed in vacuo, and the residue is acidified with concentrated hydrochloric acid. The resulting precipitate is filtered off with suction, washed with water and dried in vacuo at 50° C. 3.55 g (93.5% of theory) of the desired product are obtained.

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