Реакция #84048

Уравнение реакции

quinuclidin-3-one hydrochloride

sodium methoxide

→

title compound

Quinuclidin-3-one

Растворители

methanol

methanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe resulting precipitate is filtered off with suction
2. 2
   Концентрированиеthe filtrate is concentrated in vacuo
3. 3
   ДругоеThe residue is partitioned between chloroform and water
4. 4
   Экстракцияextracted with chloroform
5. 5
   СушкаThe combined organic phases are dried over sodium sulfate
6. 6
   Концентрированиеconcentrated in vacuo

Методика

100 g (0.62 mol) of quinuclidin-3-one hydrochloride are suspended in 2 l of methanol. At 0° C., a solution of 33.4 g (0.62 mol) of sodium methoxide in 250 ml of methanol is slowly added dropwise. The mixture is stirred at room temperature for 16 h. The resulting precipitate is filtered off with suction, and the filtrate is concentrated in vacuo. The residue is partitioned between chloroform and water and extracted with chloroform. The combined organic phases are dried over sodium sulfate and concentrated in vacuo. 58.8 g (75.9% of theory) of the title compound are obtained.

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