Реакция #84047

Уравнение реакции

barbituric acid

3,5-dibromo-2-hydroxybenzaldehyde

→

product 1a

Выход 84.6%

5-(3,5-dibromo-2-hydroxybenzylidene) perhydropyrimidine-2,4,6-trione

Выход 84.6%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Температураwhile heating
2. 2
   Другоеthe resulting reaction mixture
3. 3
   ФильтрацияThe produced crystal product was filtered
4. 4
   Промывкаwashed with cold acetic acid
5. 5
   Промывкаwashed with ether
6. 6
   Другоеair-dried

Методика

0.01 mol (1.28 g) of barbituric acid (5a) were dissolved in 25 ml of glacial acetic acid while heating. Then 0.011 mol (3.08 g) of 3,5-dibromo-2-hydroxybenzaldehyde (6a) were added to the obtained solution while stirring and the resulting reaction mixture was left at room temperature during 36 hours. The produced crystal product was filtered, washed with cold acetic acid, then washed with ether and air-dried. Thereby 3.3 g of product 1a were obtained in the form of yellow needle crystals with melting temperature of 255-260° C. (with decomposition). Output amounted to 77% of the theoretical value.

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