Реакция #84024

Уравнение реакции

t-Butanol

oxalyl chloride

→

t-butyl 2-chloro-2-oxoacetate

Выход 40.8%

Растворители

DCM

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was then concentrated in vacuo

Методика

t-Butanol (574 μL, 6.0 mmol) was added to a solution of oxalyl chloride (772 μL, 9.0 mmol) in DCM (3 mL) at 0° C., and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was then concentrated in vacuo to yield t-butyl 2-chloro-2-oxoacetate (403 mg) as a clear colorless liquid. The liquid was dissolved in DCM (2.5 mL) to prepare a 1.0 M solution in DCM.

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