Реакция #83384

Уравнение реакции

tert-butyl (2RS,5SR)-1-{2-[3-(3-(benzyloxycarbonyl)phenyl)ureido]acetyl}-2-methyl-5-phenyl-pyrrolidine-2-carboxylate

→

benzoic acid

Растворители

ethyl acetate

Условия реакции

Методика

A The reaction is carried out in a way similar to that described in Example 1A but starting from 0.54 g of tert-butyl (2RS,5SR)-1-{2-[3-(3-(benzyloxycarbonyl)phenyl)ureido]acetyl}-2-methyl-5-phenyl-pyrrolidine-2-carboxylate and 0.15 g of 10% palladium-on-charcoal in 30 cm3 of ethyl acetate. After treatment, there is obtained 0.25 g of (2RS,5SR)-3-3-2-(2-tert-butoxycarbonyl-2-methyl-5-phenyl-1-pyrrolidinyl)-2-oxoethyl]ureido}benzoic acid melting at 150° C.

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