Реакция #832896

Уравнение реакции

4,5-dimethoxy-2-nitrobenzyl alcohol

hexadecanesulfonyl chloride

→

4,5-Dimethoxy-2-nitrobenzyl hexadecanesulfonate

Растворители

acetone

dicyclohexylamine

Условия реакции

Обработка

1. 1
   Другоеover 30 minutes
2. 2
   workup.ADDITIONAfter the addition
3. 3
   ДругоеThe precipitated dicyclohexylamine hydrochloride was removed by filtration
4. 4
   Другоеhad precipitated (yield 9.5 g, m.p. 81°-82° C.)

Методика

To a solution of 5.33 g (0.025 mol) of 4,5-dimethoxy-2-nitrobenzyl alcohol and 8.15 g (0.025 mol) hexadecanesulfonyl chloride in 100 ml of acetone, dicyclohexylamine (5 ml, slight excess) was added via motor driven syringe over 30 minutes. After the addition was complete, the reaction was stirred an additional 30 minutes. The precipitated dicyclohexylamine hydrochloride was removed by filtration and the acetone filtrate reduced in volume in vacuo until most of the product had precipitated (yield 9.5 g, m.p. 81°-82° C.).

Источник