Реакция #8316

Уравнение реакции

methanol

3-benzyl-4-bromo-butyryl chloride

(1-pyridin-2-yl-2-quinolin-4-yl-ethylidene)-hydrazine

pyridine

→

title compound

3-Benzyl-4-bromo-butyric acid (1-pyridin-2-yl-2-quinolin-4-yl-ethylidene)-hydrazide

Растворители

ammonium chloride

dichloromethane

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   workup.STIRRINGstirred for 10 min
2. 2
   Промывкаwashed with water (2×50 mL) and brine (50 mL)
3. 3
   Сушкаdried with anhydrous sodium sulfate
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated in vacuo
6. 6
   ДругоеThe residue is precipitated from ether

Методика

A solution of (1-pyridin-2-yl-2-quinolin-4-yl-ethylidene)-hydrazine (2.25 g, 8.40 mmol) in anhydrous dichloromethane (100 mL) and pyridine (1.81 mL, 22.4 mmol) is cooled to −78° C., treated with a solution of 3-benzyl-4-bromo-butyryl chloride (2.1 g, 7.8 mmol) in dichloromethane (10 mL), and stirred for 2 h. The mixture is treated with methanol (3 mL), stirred for 10 min, and diluted with saturated ammonium chloride solution (30 mL). The mixture is diluted with dichloromethane (300 mL), washed with water (2×50 mL) and brine (50 mL), dried with anhydrous sodium sulfate, filtered, and concentrated in vacuo. The residue is precipitated from ether to yield the title compound, 2.3 g (60%), as a pale yellowish solid.

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