Реакция #82982

Уравнение реакции

bromide

2-amino-1-(2-piperidinoethyl)-3-(2-thenoylmethyl) benzimidazolium bromide

water

acetic anhydride

→

2-Methyl-9-(2-piperidinoethyl)-3-(2-thenoyl)imidazo [1,2-a]benzimidazole

Условия реакции

Обработка

1. 1
   workup.DISSOLUTIONuntil completely dissolved
2. 2
   ТемператураCool
3. 3
   ЭкстракцияNeutralise with a solution of sodium carbonate and extract twice with 10 ml of chloroform each time
4. 4
   Другоеevaporate
5. 5
   ДругоеRecrystallise the residue from ethyl acetate

Методика

The bromide obtained in Step A is heated at reflux in 15 ml of acetic anhydride until completely dissolved. Cool and pour into 50 ml of cold water. Neutralise with a solution of sodium carbonate and extract twice with 10 ml of chloroform each time. Combine the organic phases, pass over a column of alumina and evaporate. Recrystallise the residue from ethyl acetate.

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