Реакция #82981

Уравнение реакции

2-bromoacetylthiophene

bromine

2-amino-1-(2-piperidinoethyl)benzimidazole

→

2-amino-1-(2-piperidinoethyl)-3-(2-thenoylmethyl) benzimidazolium bromide

Растворители

acetone

Условия реакции

Обработка

1. 1
   ФильтрацияThe next day, the title compound precipitate is collected by means of filtration
2. 2
   Промывкаwashed with acetone and with ether

Методика

An ethereal solution of 2-bromoacetylthiophene (obtained by brominating 2-acetylthiophene (1.9 g, 15 mmol) with 0.8 ml (15 mmol) of bromine in 10 ml of dioxane and 15 ml of ether) is added to a hot solution of 2-amino-1-(2-piperidinoethyl)benzimidazole (2.44 g; 10 mmol) in 100 ml of acetone. Stir and maintain at room temperature. The next day, the title compound precipitate is collected by means of filtration and washed with acetone and with ether.

Источник