Реакция #8287

Уравнение реакции

2-hydroxyaceto-phenone

pyridine

acetic anhydride

→

title compound

Acetic Acid 2-oxo-2-phenyl-ethyl ester

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ПромывкаThe mixture is washed with water (200 mL) and brine (200 mL)
2. 2
   Сушкаthen dried over sodium sulfate
3. 3
   ФильтрацияThe mixture is filtered
4. 4
   Концентрированиеconcentrated in vacuo

Методика

A solution of 2-hydroxyaceto-phenone (10 g, 73.4 mmol), pyridine (17.4 g, 220.2 mmol), dichloromethane (734 mL), 3 crystals of 4-dimethylaminopyridine is cooled to −78° C. To this solution is added acetic anhydride (13.9 mL, 146.9 mmol) then warmed to room temperature and stirred for 18 h. The mixture is washed with water (200 mL) and brine (200 mL) then dried over sodium sulfate. The mixture is filtered and concentrated in vacuo to yield the title compound, 13 g (99%), as a colorless liquid.

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