Реакция #82457

Уравнение реакции

Diethyl 5-acetyl-1,6-dihydro-6-oxo-2,3pyridinedicarboxylate

N,N-dimethylformamide dineopentyl acetal

→

diethyl 5-[3-(dimethylamino)acryloyl]-1,6-dihydro-6-oxo-2,3-pyridinedicarboxylate

Выход 70.0%

Условия реакции

Обработка

1. 1
   Другоеthe product is obtained as a precipitate
2. 2
   Фильтрацияis filtered
3. 3
   Промывкаwashed with hexane
4. 4
   Другоеto yield 23.4 g, 70% yield
5. 5
   Другоеof solid which is recrystallized from isopropanol
6. 6
   Другоеto give a pure product, melting point 182°-183° C.

Методика

Diethyl 5-acetyl-1,6-dihydro-6-oxo-2,3pyridinedicarboxylate, (25 g, 0.089 mol) and N,N-dimethylformamide dineopentyl acetal (50 mL, 98%, 40.62 g, 0.176 mol) are heated for 30 minutes at 80°-100° C. After cooling to room temperature, the product is obtained as a precipitate and is filtered and washed with hexane to yield 23.4 g, 70% yield, of solid which is recrystallized from isopropanol to give a pure product, melting point 182°-183° C.

Источник