Реакция #82450

Уравнение реакции

Diethyl 6-amino-5-nitro-2,3-pyridinedicarboxylate

hydrogen

→

product

Выход 94.5%

Diethyl 5,6-diamino-2,3-pyridinedicarboxylate

Выход 94.5%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеThe catalyst is removed by filtration through a pad of Celite
2. 2
   Концентрированиеthe filtrate is concentrated

Методика

Diethyl 6-amino-5-nitro-2,3-pyridinedicarboxylate (5.00 g, 0.0176 mol) is suspended in 250 mL of absolute ethanol and the mixture cooled to 0° C. Palladium on carbon (50 g of 10% is added and the mixture is shaken under 50 psi hydrogen in a Parr apparatus for four hours. The catalyst is removed by filtration through a pad of Celite, and the filtrate is concentrated to yield 4.21 g (94.2%) of product as a yellow solid, melting point 143°-146.5° C.

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